Antimicrobial peptides and proteins in the innate defense of the airway surface

被引：112

作者：

Travis, SM

Singh, PK

Welsh, MJ

机构：

[1] Univ Iowa, Coll Med, Dept Internal Med & Physiol, Howard Hughes Med Inst, Iowa City, IA 52242 USA

[2] Univ Iowa, Coll Med, Dept Biophys, Howard Hughes Med Inst, Iowa City, IA 52242 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(00)00187-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have advanced our understanding of innate immune mechanisms that protect the airways and maintain a sterile lung. Multiple antimicrobial peptides and proteins have been identified in airway secretions and their roles are beginning to be established in animal models. Moreover, evidence for coupling between the innate and adaptive immune systems is beginning to emerge. The understanding of the innate airway defense system offers the opportunity for the development of novel therapeutic approaches.

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页码：89 / 95

页数：7

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