Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications

被引：1345

作者：

Esfand, R

Tomalia, DA

机构：

[1] Univ Michigan, Ctr Biol Nanotechnol, Ann Arbor, MI 48109 USA

[2] Dendrit Sci, Ann Arbor, MI 48104 USA

来源：

DRUG DISCOVERY TODAY | 2001年 / 6卷 / 08期

关键词：

D O I：

10.1016/S1359-6446(01)01757-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Poly(amidoamine) (PAMAM) dendrimers are the first complete dendrimer family to be synthesized, characterized and commercialized. Based on this extensive activity, they are recognized as a unique new class of synthetic nanostructures. Dendrimers allow the precise control of size, shape and placement of functional groups that is desirable for many life science applications. From this perspective, this review focuses on crucial properties of biomimetic dendrimers that will broaden the potential for their use as macromolecular vectors in novel drug delivery and biomedical applications.

引用

页码：427 / 436

页数：10

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