Axoglial junctions: Separate the channels or scramble the message

被引：19

作者：

Brophy, PJ ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Preclin Vet Sci, Edinburgh EH9 1QH, Midlothian, Scotland

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0960-9822(01)00341-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Axoglial junctions flank the nodes of Ranvier in myelinated nerves. These large cell adhesion complexes have an essential role in sequestering potassium channels located under the myelin sheath from nodal sodium channels. Recent studies have shed new light on the composition and function of axoglial junctions.

引用

页码：R555 / R557

页数：3

共 17 条

[1] Axon-glia interactions and the domain organization of myelinated axons requires Neurexin IV/Caspr/Paranodin [J].

Bhat, MA ;

Rios, JC ;

Lu, Y ;

Garcia-Fresco, GP ;

Ching, W ;

St Martin, M ;

Li, JJ ;

Einheber, S ;

Chesler, M ;

Rosenbluth, J ;

Salzer, JL ;

Bellen, HJ .

NEURON, 2001, 30 (02) :369-383

[2] Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve [J].

Boyle, MET ;

Berglund, EO ;

Murai, KK ;

Weber, L ;

Peles, E ;

Ranscht, B .

NEURON, 2001, 30 (02) :385-397

[3] Analysis of potassium channel functions in mammalian axons by gene knockouts [J].

Chiu, SY ;

Zhou, L ;

Zhang, CL ;

Messing, A .

JOURNAL OF NEUROCYTOLOGY, 1999, 28 (4-5) :349-364

[4]

Collinson JM, 1998, GLIA, V23, P11, DOI 10.1002/(SICI)1098-1136(199805)23:1<11::AID-GLIA2>3.0.CO

[5]

2-7

[6] LOCAL MODULATION OF NEUROFILAMENT PHOSPHORYLATION, AXONAL CALIBER, AND SLOW AXONAL-TRANSPORT BY MYELINATING SCHWANN-CELLS [J].

DEWAEGH, SM ;

LEE, VMY ;

BRADY, ST .

CELL, 1992, 68 (03) :451-463

[7] Axo-glial interactions regulate the localization of axonal paranodal proteins [J].

Dupree, JL ;

Girault, JA ;

Popko, B .

JOURNAL OF CELL BIOLOGY, 1999, 147 (06) :1145-1151

[8] The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination [J].

Einheber, S ;

Zanazzi, G ;

Ching, W ;

Scherer, S ;

Milner, TA ;

Peles, E ;

Salzer, JL .

JOURNAL OF CELL BIOLOGY, 1997, 139 (06) :1495-1506

[9] The glycosylphosphatidyl inositol-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/contactin-associated protein (caspr) [J].

Faivre-Sarrailh, C ;

Gauthier, F ;

Denisenko-Nehrbass, N ;

Le Bivic, A ;

Rougon, G ;

Girault, JA .

JOURNAL OF CELL BIOLOGY, 2000, 149 (02) :491-501

[10] Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice [J].

Gillespie, CS ;

Sherman, DL ;

Fleetwood-Walker, SM ;

Cottrell, DF ;

Tait, S ;

Garry, EM ;

Wallace, VCJ ;

Ure, J ;

Griffiths, IR ;

Smith, A ;

Brophy, PJ .

NEURON, 2000, 26 (02) :523-531

← 1 2 →