ROS as signalling molecules:: mechanisms that generate specificity in ROS homeostasis

被引：2862

作者：

D'Autreaux, Benoit ^{[1
]}

Toledano, Michel B. ^{[1
]}

机构：

[1] CEA, IBITECS, SBIGEM, Lab Stress Oxydants Canc, F-91191 Gif Sur Yvette, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 10期

关键词：

D O I：

10.1038/nrm2256

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactive oxygen species ( ROS) have been shown to be toxic but also function as signalling molecules. This biological paradox underlies mechanisms that are important for the integrity and fitness of living organisms and their ageing. The pathways that regulate ROS homeostasis are crucial for mitigating the toxicity of ROS and provide strong evidence about specificity in ROS signalling. By taking advantage of the chemistry of ROS, highly specific mechanisms have evolved that form the basis of oxidant scavenging and ROS signalling systems.

引用

页码：813 / 824

页数：12

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