Role of IL-10 in allergen-specific immunotherapy and normal response to allergens

被引：38

作者：

Akdis, CA ^{[1
]}

Blaser, K ^{[1
]}

机构：

[1] Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 11期

关键词：

interleukin-10; specific immunotherapy; tolerance; anergy; CD28;

D O I：

10.1016/S1286-4579(01)01449-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Induction of specific unresponsiveness (tolerance/anergy) in peripheral T cells by interleukin-10 (IL-10) and recovery by cytokines from the tissue microenvironment represent two key steps in specific immunotherapy of allergy and in natural exposure to allergens in healthy individuals. IL-10 elicits anergy in T cells by selective inhibition of the CD28 costimulatory pathway and controls suppression and development of antigen-specific immunity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：891 / 898

页数：8

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