Comparison of fine-scale recombination rates in humans and chimpanzees

被引：285

作者：

Winckler, W

Myers, SR

Richter, DJ

Onofrio, RC

McDonald, GJ

Bontrop, RE

McVean, GAT

Gabriel, SB

Reich, D

Donnelly, P ^{[1
]}

Altshuler, D

机构：

[1] Univ Oxford, Dept Stat, Oxford OX1 3TG, England

[2] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Dept Med, Diabet Unit, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[7] Harvard Univ, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02141 USA

[8] MIT, Cambridge, MA 02141 USA

[9] Biomed Primate Res Ctr, Dept Comparat Genet & Refinement, NL-2280 GH Rijswijk, Netherlands

来源：

SCIENCE | 2005年 / 308卷 / 5718期

关键词：

D O I：

10.1126/science.1105322

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite similar to 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.

引用

页码：107 / 111

页数：5

共 23 条

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