Selective aldosterone blockade with eplerenone in patients with congestive heart failure

被引：8

作者：

Salam, AM ^{[1
]}

机构：

[1] Hamad Med Corp, Dept Cardiol & Cardiovasc Surg, Doha, Qatar

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2003年 / 12卷 / 08期

关键词：

aldosterone; congestive heart failure; eplerenone; paper evaluation; spironolactone; trials;

D O I：

10.1517/eoid.12.8.1423.21781

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the Eplerenone Postacute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) the effects of selective aldosterone blockade with eplerenone on cardiovascular mortality and morbidity Were studied in patients with reduced left ventricular function postacute myocardial infarction. Data from this landmark study suggest that eplerenone can be an effective addition to the therapy of patients with congestive heart failure and is associated with fewer side effects than spironolactone. Further research is warranted concerning the possible benefits of this new agent in disease states other than congestive heart failure in which an activated renin-angiotensin-aldosterone system system has been implicated.

引用

页码：1423 / 1427

页数：5

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