Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?

被引：30

作者：

Binard, Aymeric ^{[1
,2
]}

Le Pottier, Laeitia ^{[1
]}

Saraux, Alain ^{[2
]}

Devauchelle-Pensec, Valerie ^{[1
,2
]}

Pers, Jacques-Olivier ^{[1
]}

Youinou, Pierre ^{[1
]}

机构：

[1] Brest Univ, Med Sch Hosp, Immunol Lab, F-29609 Brest, France

[2] Brest Univ, Med Sch Hosp, Rheumatol Unit, F-29609 Brest, France

来源：

JOURNAL OF AUTOIMMUNITY | 2008年 / 30卷 / 1-2期

关键词：

systemic lupus erythematosus; BAFF; B lymphocyte;

D O I：

10.1016/j.jaut.2007.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Given the prominent role currently assigned to B lymphocytes in systemic lupus erythematosus, it is not surprising that the B cell activity factor belonging to the tumor necrosis factor family (BAFF) is involved in its pathogenesis. This cytokine is produced in excess, and inserted into its receptors on the surface of circulating B cells. Up-regulation of BAFF is most likely to lead to breach of tolerance by aberrant survival of B cells directed to the self. Trials aimed at blocking BAFF have thus been set out. Yet the results are awaited. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：63 / 67

页数：5

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