Tissue inhibitors of metalloproteinases and metalloproteinases in atherosclerosis

被引：67

作者：

George, SJ ^{[1
]}

机构：

[1] Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England

来源：

CURRENT OPINION IN LIPIDOLOGY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1097/00041433-199810000-00005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of the metalloproteinases to degrade extracellular matrix proteins is essential for the matrix remodelling that occurs during infiltration of inflammatory cells, intimal thickening, angiogenesis and plaque rupture which are a result of atherosclerosis. Increased metalloproteinase activity therefore requires stimulation of metalloproteinase expression by cytokines and growth factors, activation of metalloproteinases, and downregulation of tissue inhibitors of metalloproteinases. In addition, metalloproteinases may influence atherosclerosis by processing of proteins involved in inflammation and cell growth and death and the tissue inhibitors of metalloproteinases may also play a less inhibitory role by influencing cell growth and apoptosis. Curr Opin Lipidol 9:413-423. (C) 1998 Lippincott Williams & Wilkins

引用

页码：413 / 423

页数：11

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