Changes in renal function associated with tenofovir disoproxil fumarate treatment, compared with nucleoside reverse-transcriptase inhibitor treatment

被引：219

作者：

Gallant, JE ^{[1
]}

Parish, MA ^{[1
]}

Keruly, JC ^{[1
]}

Moore, RD ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21287 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2005年 / 40卷 / 08期

关键词：

D O I：

10.1086/428840

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In our large observational cohort, use of tenofovir disoproxil fumarate (n = 344) was associated with a greater decline in renal function than was use of alternative nucleoside analogues (n = 314). Other associations included a lower CD4 cell count, decreased renal function at baseline, and diabetes. The declines were modest and did not lead to greater rates of discontinuation of therapy.

引用

页码：1194 / 1198

页数：5

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