Hepatocellular carcinoma in the thalassaemia syndromes

被引：136

作者：

Borgna-Pignatti, C

Vergine, G

Lombardo, T

Cappellini, MD

Cianciulli, P

Maggio, A

Renda, D

Lai, ME

Mandas, A

Forni, G

Piga, A

Bisconte, MG

机构：

[1] Univ Ferrara, Dipartimento Med Clin & Sperimentale Pediat, Pediat Clin, I-44100 Ferrara, Italy

[2] Ctr Thalassemia, Santo Bambino Catania, Italy

[3] Univ Milan, Dipartimento Med, Milan, Italy

[4] Osped S Eugenio, Day Hosp Thalassemia, Rome, Italy

[5] Osped Cervello, Div Ematol 2, Palermo, Italy

[6] Univ Cagliari, Sez Talassemici Adulti, Dipartimento Sci Med, I-09124 Cagliari, Italy

[7] Osped Galliera, Div Pediat, Genoa, Italy

[8] Univ Turin, Dipartimento Pediat, Turin, Italy

[9] Ctr Studio Microcitemia, Cosenza, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 124卷 / 01期

关键词：

hepatocellular carcinoma; thalassaemia; hepatitis C; cirrhosis; iron overload;

D O I：

10.1046/j.1365-2141.2003.04732.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty-two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 +/- 11 years and the mean serum ferritin was 1764 +/- 1448 mug/l. Eighty-six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.

引用

页码：114 / 117

页数：4

共 12 条

[1] Survival and disease complications in thalassemia major [J].