Adipose tissue, adipokines, and inflammation

被引:1932
作者
Fantuzzi, G [1 ]
机构
[1] Univ Illinois, Dept Human Nutr, Chicago, IL 60612 USA
关键词
obesity; inflmmation; inimunity; cytokines; adipokines; insulin resistance; adipose tissue;
D O I
10.1016/j.jaci.2005.02.023
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
White adipose tissue is no longer considered an inert tissue mainly devoted to energy storage but is emerging as an active participant in regulating physiologic and pathologic processes, including immunity and inflammation. Macrophages are components of adipose tissue and actively participate in its activities. Furthermore, cross-talk between lymphocytes and adipocytes can lead to immune regulation. Adipose tissue produces and releases a variety of proinflammatory and antiinflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as TNF-alpha, IL-6, monocyte chemoattractant protein 1, and others. Proinflammatory molecules produced by adipose tissue have been implicated as active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. In contrast, reduced leptin levels might predispose to increased susceptibility to infection caused by reduced T-cell responses in malnourished individuals. Altered adipokine levels have been observed in a variety of inflammatory conditions, although their pathogenic role has not been completely clarified.
引用
收藏
页码:911 / 919
页数:9
相关论文
共 89 条
[1]   Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis [J].
Anders, HJ ;
Rihl, M ;
Heufelder, A ;
Loch, O ;
Schattenkirchner, M .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1999, 48 (06) :745-748
[2]   IKK-β links inflammation to obesity-induced insulin resistance [J].
Arkan, MC ;
Hevener, AL ;
Greten, FR ;
Maeda, S ;
Li, ZW ;
Long, JM ;
Wynshaw-Boris, A ;
Poli, G ;
Olefsky, J ;
Karin, M .
NATURE MEDICINE, 2005, 11 (02) :191-198
[3]  
Babadzhanova GY, 2003, TERAPEVT ARKH, V75, P18
[4]   Plasma leptin in chronic inflammatory bowel disease and HIV: implications for the pathogenesis of anorexia and weight loss [J].
Ballinger, A ;
Kelly, P ;
Hallyburton, E ;
Besser, R ;
Farthing, M .
CLINICAL SCIENCE, 1998, 94 (05) :479-483
[5]  
Barbier M, 2003, GASTROEN CLIN BIOL, V27, P987
[6]   Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta [J].
Batocchi, AP ;
Rotondi, M ;
Caggiula, M ;
Frisullo, G ;
Odoardi, F ;
Nociti, V ;
Carella, C ;
Tonali, PA ;
Mirabella, M .
JOURNAL OF NEUROIMMUNOLOGY, 2003, 139 (1-2) :150-154
[7]  
Beltowski Jerzy, 2003, Med Sci Monit, V9, pRA55
[8]   Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice [J].
Bernotiene, E ;
Palmer, G ;
Talabot-Ayer, D ;
Szalay-Quinodoz, I ;
Aubert, ML ;
Gabay, C .
ARTHRITIS RESEARCH & THERAPY, 2004, 6 (03) :R256-R263
[9]   Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men [J].
Boudou, P ;
Sobngwi, E ;
Mauvais-Jarvis, F ;
Vexiau, P ;
Gautier, JF .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 149 (05) :421-424
[10]   Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis [J].
Busso, N ;
So, A ;
Chobaz-Péclat, V ;
Morard, C ;
Martinez-Soria, E ;
Talabot-Ayer, D ;
Gabay, C .
JOURNAL OF IMMUNOLOGY, 2002, 168 (02) :875-882