Blockade of K-ATP channels with glibenclamide does not abolish preconditioning during demand ischemia

被引：28

作者：

Correa, SD

Schaefer, S

机构：

[1] Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA

[2] Div. of Cardiovasc. Medicine, TB 172, University of California, Davis

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1997年 / 79卷 / 01期

关键词：

D O I：

10.1016/S0002-9149(96)00681-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of adenosine triphosphate-sensitive potassium channels in the adaptive response to demand ischemia was tested in 22 patients treated with placebo or glibenclamide before sequential exercise testing or atrial pacing, Glibenclamide did not affect the improvement in signs of ischemia in both protocols, indicating that opening of these channels is not a mechanism of this adaptive response in humans.

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页码：75 / &

页数：5

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