Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

被引：416

作者：

Peter, ME ^{[1
]}

Krammer, PH ^{[1
]}

机构：

[1] German Canc Res Ctr, Tumor Immunol Program, D-69120 Heidelberg, Germany

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(98)80222-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CD95-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.

引用

页码：545 / 551

页数：7

共 99 条

[1] Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during fas-mediated apoptosis [J].

Adachi, S ;

Cross, AR ;

Babior, BM ;

Gottlieb, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (35) :21878-21882

[2] Human ICE/CED-3 protease nomenclature [J].

Alnemri, ES ;

Livingston, DJ ;

Nicholson, DW ;

Salvesen, G ;

Thornberry, NA ;

Wong, WW ;

Yuan, JY .

CELL, 1996, 87 (02) :171-171

[3] Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis:: protection is correlated with up regulation of Bcl-xL [J].

Amarante-Mendes, GP ;

McGahon, AJ ;

Nishioka, WK ;

Afar, DEH ;

Witte, ON ;

Green, DR .

ONCOGENE, 1998, 16 (11) :1383-1390

[4] Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L [J].

Aragane, Y ;

Kulms, D ;

Metze, D ;

Wilkes, G ;

Pöppelmann, B ;

Luger, TA ;

Schwarz, T .

JOURNAL OF CELL BIOLOGY, 1998, 140 (01) :171-182

[5] CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase [J].

Boesen-de Cock, JGR ;

Tepper, AD ;

de Vries, E ;

van Blitterswijk, WJ ;

Borst, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (13) :7560-7565

[6] A NOVEL PROTEIN THAT INTERACTS WITH THE DEATH DOMAIN OF FAS/APO1 CONTAINS A SEQUENCE MOTIF RELATED TO THE DEATH DOMAIN [J].

BOLDIN, MP ;

VARFOLOMEEV, EE ;

PANCER, Z ;

METT, IL ;

CAMONIS, JH ;

WALLACH, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (14) :7795-7798

[7] Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death [J].

Boldin, MP ;

Goncharov, TM ;

Goltsev, YV ;

Wallach, D .

CELL, 1996, 85 (06) :803-815

[8] Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization [J].

Bossy-Wetzel, E ;

Newmeyer, DD ;

Green, DR .

EMBO JOURNAL, 1998, 17 (01) :37-49

[9]

Cahill MA, 1996, ONCOGENE, V13, P2087

[10] Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis [J].

Caulin, C ;

Salvesen, GS ;

Oshima, RG .

JOURNAL OF CELL BIOLOGY, 1997, 138 (06) :1379-1394

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