Chemokines and lymphopoiesis in human thymus

被引：60

作者：

Annunziato, F

Romagnani, P

Cosmi, L

Lazzeri, E

Romagnani, S

机构：

[1] Univ Florence, Dept Internal Med, Sect Immunoallergol & Resp Dis, I-50134 Florence, Italy

[2] Univ Florence, Dept Clin Physiopathol, Endocrinol Sect, I-50134 Florence, Italy

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 05期

关键词：

D O I：

10.1016/S1471-4906(01)01889-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Distinct and redundant chemokines are responsible for organizing the extraordinarily diverse thymocyte populations into discrete microenvironments, from the arrival of immature precursors in the thymus to the migration of different mature cell types to the periphery. We propose that, by selectively mobilizing cells, chemokines can sort positively selected cells from negatively selected cells, and that chemokines make distinctions among CD8(+) subpopulations that previously have not been recognized.

引用

页码：277 / 281

页数：5

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