Oxidized low-density lipoprotein induces the production of interleukin-8 by endothelial cells

被引：33

作者：

Claise, C

Edeas, M

Chalas, J

Cockx, A

Abella, A

Capel, L

Lindenbaum, A

机构：

[1] Department of Biochemistry, Hosp. Antoine Béclère, 92141 Clamart Cedex

来源：

FEBS LETTERS | 1996年 / 398卷 / 2-3期

关键词：

atherosclerosis; oxidized low-density lipoprotein; EA.hy 926 endothelial cell; interleukin-8; RANTES; reactive oxygen species;

D O I：

10.1016/S0014-5793(96)01255-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The concentration of interleukin-8 (IL-8) and RANTES was measured in culture supernatants of human EA.hy 926 endothelial cells incubated with oxidized low-density lipoproteins (LDL). Oxidized LDL induced a 3-fold increase in IL-8 production (p < 0.01), whereas RANTES was not detected, Native LDL did not stimulate IL-8 production, IL-8 production in oxidized-LDL-treated cells was mediated by reactive oxygen species, as it was partially inhibited by catalase and completely inhibited by glutathione peroxidase and N-acetylcysteine (p < 0.01).

引用

页码：223 / 227

页数：5

共 52 条

[1] HYPOXIA REOXYGENATION STIMULATES ENDOTHELIAL-CELLS TO PROMOTE INTERLEUKIN-1 AND INTERLEUKIN-6 PRODUCTION - EFFECTS OF FREE-RADICAL SCAVENGERS [J].