Stretching exercises - flexibility in dihydrofolate reductase catalysis

被引：94

作者：

Miller, GP ^{[1
]}

Benkovic, SJ ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 05期

关键词：

D O I：

10.1016/S1074-5521(98)90616-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As an enzyme, dihydrofolate reductase performs two tasks: transformation of its substrate dihydrofolate or folate to tetrahydrofolate, using NADPH as a cofactor, and regeneration of the enzyme for a subsequent round of catalysis. Studies discussed in this review highlight the role of conformational flexibility in both of these enzymatic functions.

引用

页码：R105 / R113

页数：9

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