Is the DNA repair system involved in hepatitis-B-virus mediated hepatocellular carcinogenesis?

被引：19

作者：

Butel, JS ^{[1
]}

Lee, TH ^{[1
]}

Slagle, BL ^{[1
]}

机构：

[1] BAYLOR COLL MED, DIV MOLEC VIROL, HOUSTON, TX 77030 USA

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 03期

关键词：

D O I：

10.1016/0966-842X(96)81529-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new model is proposed for the involvement of hepatitis B virus (HBV) in human liver cancer at the molecular level. The HBV X protein interacts with a cellular protein involved in DNA repair. Coupled with the effects of long-term chronic infection by HBV, this model suggests a novel mechanism for human tumor viruses that act indirectly.

引用

页码：119 / 124

页数：6

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