FIP200, a key signaling node to coordinately regulate various cellular processes

被引：59

作者：

Gan, Boyi ^{[2
]}

Guan, Jun-Lin ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Div Mol Med & Genet, Ann Arbor, MI 48109 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

CELLULAR SIGNALLING | 2008年 / 20卷 / 05期

关键词：

FIP200; signal transduction; cell size control; cell survival; cell proliferation;

D O I：

10.1016/j.cellsig.2007.10.021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A central question in cell biology is how various cellular processes are coordinately regulated in normal cell and how dysregulation of the normal signaling pathways leads to diseases such as cancer. Recent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development. Further understanding of FIP200 function might provide novel therapeutic targets for human diseases such as cancer. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：787 / 794

页数：8

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