α-Bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices

被引：231

作者：

Alkondon, M

Pereira, EFR

Albuquerque, EX

机构：

[1] Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA

[2] Univ Fed Rio de Janeiro, Hlth Sci Ctr, Inst Biomed Sci, Dept Basic & Clin Pharmacol, BR-21944 Rio De Janeiro, Brazil

来源：

BRAIN RESEARCH | 1998年 / 810卷 / 1-2期

关键词：

synaptic transmission; methyllycaconitine; nicotinic receptor; hippocampus; slice;

D O I：

10.1016/S0006-8993(98)00880-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study demonstrates for the first time that alpha 7 nicotinic receptors (nAChRs) mediate fast synaptic transmission in conventional hippocampal slices. In the presence of antagonists of muscarinic, AMPA, NMDA, GABA(A), ATP, and 5-HT3 receptors, spontaneous and evoked postsynaptic currents (PSCs) recorded from CA1 interneurons were blocked by the alpha 7 nAChR antagonists methyllycaconitine and alpha-bungarotoxin and by a desensitizing concentration of the alpha 7 nAChR agonist choline. Spontaneous nicotinic PSCs were also accompanied by Na+ transients, indicating that alpha 7 nAChR-mediated transmission serves as an excitatory signal to the CA1 interneurons in the hippocampus. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：257 / 263

页数：7

共 40 条

[1] Contribution of nicotinic receptors to the function of synapses in the central nervous system:: The action of choline as a selective agonist of α7 receptors [J].