The envelope of Mason-Pfizer monkey virus has immunosuppressive properties

被引：43

作者：

Blaise, S ^{[1
]}

Mangeney, M ^{[1
]}

Heidmann, T ^{[1
]}

机构：

[1] Inst Gustave Roussy, Unite Retrovirus Endogenes & Elements Retroides E, CNRS, UMR 1573, F-94805 Villejuif, France

来源：

JOURNAL OF GENERAL VIROLOGY | 2001年 / 82卷

关键词：

D O I：

10.1099/0022-1317-82-7-1597

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have demonstrated previously that the envelope protein of a murine retrovirus, Moloney murine leukaemia virus, has immunosuppressive properties in vivo. This property was manifested by the ability of the protein, when expressed by tumour cells normally rejected by engrafted mice, to allow the env-expressing cells to escape immune rejection and to proliferate. Here, it is shown that this property is not restricted to the envelope of a murine retrovirus, but is also shared by the envelope encoded by a primate retrovirus, Mason-Pfizer monkey virus.

引用

页码：1597 / 1600

页数：4

共 18 条

[1]

ARTHUR LO, 1986, PROG ALLERGY, V37, P332

[2] MOLECULAR-CLONING OF THE MASON PFIZER MONKEY VIRUS GENOME - BIOLOGICAL CHARACTERIZATION OF GENOME LENGTH CLONES AND MOLECULAR COMPARISONS TO OTHER RETROVIRUSES [J].