Anti-influenza virus activities of flavonoids from the medicinal plant Elsholtzia rugulosa

被引：133

作者：

Liu, Ai-Lin ^{[1
,2
,3
]}

Liu, Bo ^{[2
,3
]}

Qin, Hai-Lin ^{[2
,3
]}

Lee, Simon Ming Yuen ^{[1
]}

Wang, Yi-Tao ^{[1
]}

Du, Guan-Hua ^{[2
,3
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, Taipa, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

来源：

PLANTA MEDICA | 2008年 / 74卷 / 08期

关键词：

Elsholtzia rugulosa; Lamiaceae; flavonoids; influenza virus; neuraminidase (NA);

D O I：

10.1055/s-2008-1074558

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Elsholtzia rugulosa (Lamiaceae), a common Chinese herb, is widely used in the treatment of cold and fever. In order to elucidate the action mechanism and the active principles from the plant against anti-influenza virus, the influenza virus neuraminidase (NA) activity assay and in vitro antiviral activity assay were established, and the isolation of the active principles was guided by NA activity. Finally, 5 active constituents were obtained, namely apigenin (1), luteolin (2), apiin (3), galuteolin (4) and luteolin 3'-glucuronyl acid methyl ester (5), respectively. They all belong to the flavonoids. The in vitro antiviral assay using a cytopathic effect (CPE) reduction method showed that they all possessed anti-influenza virus activity. Among them, apigenin and luteolin exhibited the highest activities against influenza virus (H3N2) with IC50 values of 1.43 mu g/mL and 2.06 mu g/mL, respectively. The structure-activity relationship (SAR) of these flavonoids with different chemical structures and their anti-influenza virus activities was addressed in this study.

引用

页码：847 / 851

页数：5

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