Association of the toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events

被引:203
作者
Ameziane, N
Beillat, T
Verpillat, P
Chollet-Martin, S
Aumont, MC
Seknadji, P
Lamotte, M
Lebret, D
Ollivier, V
de Prost, D
机构
[1] Hop Louis Mourier, Serv Hematol Biol & Immunol, F-92701 Colombes, France
[2] Fac Xavier Bichat, INSERM, U479, Paris, France
[3] Hop Louis Mourier, Dept Sante Publ, AP HP, F-92701 Colombes, France
[4] Hop Louis Mourier, FGC Genet, F-92701 Colombes, France
[5] Hop Bichat Claude Bernard, Serv Cardiol A, AP HP, F-75877 Paris 18, France
关键词
TLR4; acute coronary events; genetics;
D O I
10.1161/01.ATV.0000101191.92392.1D
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective - Atherosclerosis is a chronic inflammatory disease of the blood vessels. Toll-like receptor 4 (TLR4) is a transmembrane receptor that is involved in mediating inflammatory responses to bacterial endotoxin and other ligands. The aim of this study was to search for an association between a common functional polymorphism of TLR4 Asp299Gly - and acute coronary syndrome. Methods and Results - We conducted a case-control study of 183 patients with acute coronary syndromes and 216 controls. We screened the TLR4 gene for the Asp299Gly polymorphism using a 5' fluorogenic assay. The 299Gly allele was associated with a decreased risk of acute coronary events independently of standard coronary risk factors. The adjusted odds ratio associated with this allele was 0.41 (95% CI, 0.18 to 0.95; P = 0.037). In controls, TLR4 heterozygosity was also associated with a significant decrease in plasma fibrinogen and soluble vascular cellular adhesion molecule-1 levels ( P < 0.01). Conclusions - These results, which must be confirmed by a prospective longitudinal study, provide evidence of an association between the Asp299Gly polymorphism of the human TLR4 receptor and acute coronary syndromes. They confirm the previously reported involvement of TLR4 in carotid and femoral artery atherosclerosis.
引用
收藏
页码:E61 / E64
页数:4
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