RAP, a novel type of ER chaperone

被引：92

作者：

Bu, GJ ^{[1
]}

Schwartz, AL

机构：

[1] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(98)01283-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

引用

页码：272 / 276

页数：5

共 47 条

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