Thrombospondins and tumor angiogenesis

被引：155

作者：

de Fraipont, F

Nicholson, AC

Feige, JJ

Van Meir, EG ^{[1
]}

机构：

[1] Emory Univ, Dept Neurosurg, Mol Neurooncol Lab, Atlanta, GA 30322 USA

[2] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[3] CEA, Dept Mol & Struct Biol, INSERM, EMI 0105, Grenoble, France

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 09期

关键词：

D O I：

10.1016/S1471-4914(01)02102-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The thrombospondins (TSPs) are a family of five secreted proteins that are widely distributed in the extracellular matrix of numerous tissues. TSPs are multimodular and each domain specifies a distinct biological function through interaction with a specific receptor. TSP1 and TSP2 have anti-angiogenic activity, which, at least for TSP1, involves interaction with the microvascular endothelial cell receptor CD36. Expression of TSP1 and TSP2 is modulated by hypoxia and by oncogenes. In several tumors (thyroid, colon, bladder carcinomas), TSP1 expression is inversely correlated with tumor grade and survival rate, whereas in others (e.g. breast carcinomas), it is correlated with the stromal response and is of little prognostic value. Recent studies suggest that TSPs or TSP-derived peptides retaining biological activity could be developed into promising new therapeutic strategies for the anti-angiogenic treatment of solid tumors.

引用

页码：401 / 407

页数：7

共 78 条

[1] Accelerated Publication -: Activation of platelet-transforming growth factor β-1 in the absence of thrombospondin-1 [J].