Killing cancer cells by flipping the Bcl-2/Bax switch

被引：262

作者：

Cory, S

Adams, JM

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

来源：

CANCER CELL | 2005年 / 8卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2005.06.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

impairment of apoptosis, the physiologic cell death process, is central to cancer development and renders tumors refractory to cytotoxic therapy. Bcl-2, the oncoprotein activated in follicular lymphoma, inhibits the conserved cell death pathway triggered by diverse cytotoxic agents, as do several close relatives. A small-molecule antagonist of these proteins has now been designed by Oltersdorf et al. Strikingly, ABT 737 sensitizes many tumors to cytotoxic agents and is effective as a single agent against certain lymphomas and solid tumors, provoking stable regression in some tumor xenografts. Hence, this work validates Bcl-2-like proteins as important new targets in cancer therapy.

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页码：5 / 6

页数：2

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