A neural circuit for circadian regulation of arousal

被引：433

作者：

Aston-Jones, G ^{[1
]}

Chen, S ^{[1
]}

Zhu, Y ^{[1
]}

Oshinsky, ML ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Psychiat, VAMC, Philadelphia, PA 19104 USA

来源：

NATURE NEUROSCIENCE | 2001年 / 4卷 / 07期

关键词：

D O I：

10.1038/89522

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indirect projection from the SCN to the noradrenergic nucleus locus coeruleus (LC), a brain arousal system. Double-labeling experiments revealed several possible links between the SCN and the LC, including the dorsomedial (DMH) and paraventricular hypothalamic nuclei (PVN), as well as medial and ventrolateral pre-optic areas. Lesion studies confirmed that the DMH is a substantial relay in this circuit. Next, neurophysiology experiments revealed circadian variations in LC impulse activity. Lesions of the DMH eliminated these circadian changes in LC activity, confirming the functionality of the SCN-DMH-LC circuit. These results reveal mechanisms for regulation of circadian and sleep-waking functions.

引用

页码：732 / 738

页数：7

共 48 条

[1] SIMULATION OF DAYTIME VIGILANCE BY THE ADDITIVE INTERACTION OF A HOMEOSTATIC AND A CIRCADIAN PROCESS [J].

ACHERMANN, P ;

BORBELY, AA .

BIOLOGICAL CYBERNETICS, 1994, 71 (02) :115-121

[2]

AGHAJANIAN GK, 1975, BRAIN RES, V88, P221, DOI 10.1016/0006-8993(75)90386-8

[3] Use of pseudorabies virus to delineate multisynaptic circuits in brain: opportunities and limitations [J].

Aston-Jones, G ;

Card, JP .

JOURNAL OF NEUROSCIENCE METHODS, 2000, 103 (01) :51-61

[4]

Aston-Jones G, 2000, PROG BRAIN RES, V126, P165

[5]

Aston-Jones Gary, 1995, P183

[6] THE BRAIN NUCLEUS LOCUS-COERULEUS - RESTRICTED AFFERENT CONTROL OF A BROAD EFFERENT NETWORK [J].

ASTONJONES, G ;

ENNIS, M ;

PIERIBONE, VA ;

NICKELL, WT ;

SHIPLEY, MT .

SCIENCE, 1986, 234 (4777) :734-737

[7]

ASTONJONES G, 1981, J NEUROSCI, V1, P876

[8] VENTROMEDIAL AND DORSOMEDIAL HYPOTHALAMIC SYNDROMES IN THE WEANLING RAT - IS THE CENTER CONCEPT REALLY OUTMODED [J].

BERNARDIS, LL .

BRAIN RESEARCH BULLETIN, 1985, 14 (06) :537-549

[9]

Bernardis LL, 1998, P SOC EXP BIOL MED, V218, P284

[10]

BERRIDGE CW, 1991, J NEUROSCI, V11, P3135

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