Atherosclerotic plaque rupture: a fatigue process?

被引：35

作者：

Bank, AJ

Versluis, A

Dodge, SM

Douglas, WH

机构：

[1] Univ Minnesota, St Paul Heart Clin, Dept Med, Div Cardiovasc, St Paul, MN 55102 USA

[2] Univ Minnesota, Minnesota Dent Res Ctr Biomat & Biomech, St Paul, MN 55102 USA

来源：

MEDICAL HYPOTHESES | 2000年 / 55卷 / 06期

关键词：

D O I：

10.1054/mehy.2000.1096

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The mechanism of atherosclerotic: plaque rupture is not known. Current theories focus on the acute triggers of plaque rupture and myocardial infarction such as increased shear or circumferential stress, rupture of the vasa vasorum and vasospasm. We hypothesize that a critical mechanism causing plaque rupture is fatigue failure, the catastrophic rupture of a material following exposure to high-cycle, low-amplitude repetitive stress.. Comparisons between material fatigue and plaque rupture demonstrate that this hypothesis is consistent with known physiologic and epidemiologic data on plaque rupture. (C) 2000 Harcourt Publishers Ltd.

引用

页码：480 / 484

页数：5

共 34 条

[1] Association of average heart rate on 24-hour ambulatory electrocardiograms with incidence of new coronary events at 48-month follow-up in 1,311 patients (mean age 81 years) with heart disease and sinus rhythm [J].