Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP

被引：99

作者：

Calabresi, P

Centonze, D

Gubellini, P

Bernardi, G

机构：

[1] Univ Rome, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy

[2] CNR, Ist Med Sperimentale, I-00137 Rome, Italy

[3] Osped S Lucia, IRCCS, Rome, Italy

来源：

NEUROPHARMACOLOGY | 1999年 / 38卷 / 02期

关键词：

acetylcholine; intracellular recordings; striatum; synaptic plasticity;

D O I：

10.1016/S0028-3908(98)00199-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the role of endogenous acetylcholine (Ach) in corticostriatal long-term potentiation (LTP). The muscarinic receptor antagonists scopolamine and pirenzepine fully prevented the induction of LTP suggesting that the activation of Mi-like muscarinic receptors is a crucial event in the conditioning phase of this form of synaptic plasticity. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：323 / 326

页数：4

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