Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells

被引：710

作者：

Butovsky, O

Ziv, Y

Schwartz, A

Landa, G

Talpalar, AE

Pluchino, S

Martino, G

Schwartz, M ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

[2] Kaplan Med Ctr, IL-76100 Rehovot, Israel

[3] San Raffaele Sci Inst, Dept Biotechnol, Neuroimmunol Unit, I-20132 Milan, Italy

[4] San Raffaele Sci Inst, Dept Neurol, Neuroimmunol Unit, I-20132 Milan, Italy

[5] San Raffaele Sci Inst, Dept Neurophysiol, Neuroimmunol Unit, I-20132 Milan, Italy

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2006年 / 31卷 / 01期

关键词：

D O I：

10.1016/j.mcn.2005.10.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell renewal in the adult central nervous system (CNS) is limited, and is blocked in inflammatory brain conditions. we show that both neurogenesis and oligodendrogenesis of adult neural progenitor cells in mice are blocked by inflammation-associated (endotoxin-activated) microglia, but induced by microglia activated by cytokines (IL-4 or low level of IFN-gamma) associated with T-helper cells. Blockage was correlated with up-regulation of microglial production of tumor necrosis factor-a. The effect induced by IL-4-activated microglia was mediated, at least in part, by insulin-like growth factor-I. The IL-4-activated microglia showed a bias towards oligodendrogenesis whereas the IFN-gamma-activated microglia showed a bias towards neurogenesis. It thus appears that microglial phenotype critically affects their ability to support or impair cell renewal from adult stem cell. (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：149 / 160

页数：12

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