The soluble interleukin-2 receptor as an indicator of clinical evolution in patients with ulcerative colitis

被引：8

作者：

Balzano, A ^{[1
]}

Bove, A ^{[1
]}

Leonardi, E ^{[1
]}

Bevilacqua, N ^{[1
]}

Grande, G ^{[1
]}

Ascierto, PA ^{[1
]}

Castello, G ^{[1
]}

机构：

[1] A CARDARELLI HOSP,DEPT GASTROENTEROL,NAPLES,ITALY

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1997年 / 9卷 / 02期

关键词：

soluble interleukin-2 receptor; ulcerative colitis;

D O I：

10.1097/00042737-199702000-00012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/aims: The soluble interleukin-2 receptor is a useful, non-specific marker of in-vivo activated cellular immune functions. The aim of this study was to evaluate the correlation between this marker and clinical evolution of ulcerative colitis. Methods: Serum soluble interleukin-2 receptor levels were determined, by an enzyme immune assay, in 105 patients affected by ulcerative colitis with different extent and activity of disease. Forty-six of these patients were restaged in a follow-up study, and their serum-soluble interleukin-2 receptor concentrations were measured again. Results: Serum soluble interleukin-2 receptor level is higher in pan-ulcerative colitis than in left ulcerative colitis (P=0.050) and much higher in active than in quiescent stage of disease (P=0.029). Clinical relapse of disease is accompanied by a serum soluble interleukin-2 receptor rise (P=0.0697), whereas clinical and histological improvement in disease is accompanied by its significant decrease (P=0.0009). Conclusion: In ulcerative colitis the serum determination of soluble interleukin-2 receptor is a useful and non-invasive marker of activity, and also extension and evolution of the disease.

引用

页码：173 / 177

页数：5

共 31 条

[1] FLOW CYTOMETRIC ANALYSIS OF LYMPHOCYTES ISOLATED FROM ENDOSCOPIC BIOPSIES IN ULCERATIVE-COLITIS [J].