Chlamydia trachomatis IncA is localized to the inclusion membrane and is recognized by antisera from infected humans and primates

被引：83

作者：

Bannantine, JP

Stamm, WE

Suchland, RJ

Rockey, DD

机构：

[1] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA

[2] Univ Washington, Sch Med, Div Allergy & Infect Dis, Seattle, WA 98195 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 12期

关键词：

D O I：

10.1128/IAI.66.12.6017-6021.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chlamydia psittaci produces a collection of proteins, termed IncA, IncB, and IncC, that are localized to the chlamydial inclusion membrane. In this report we demonstrate that IncA is also produced by Chlamydia trachomatis. C. trachomatis IncA is structurally similar to C. psittaci IncA and is also localized to the inclusion membrane. Immunoblot analysis demonstrated that sera from C. trachomatis-infected patients and from experimentally infected monkeys both recognized C. trachomatis IncA.

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页码：6017 / 6021

页数：5

相关论文

共 24 条

[1] Tandem genes of Chlamydia psittaci that encode proteins localized to the inclusion membrane [J].

Bannantine, JP ;

Rockey, DD ;

Hackstadt, T .

MOLECULAR MICROBIOLOGY, 1998, 28 (05) :1017-1026

[2] MONOCLONAL-ANTIBODY AGAINST A GENUS-SPECIFIC ANTIGEN OF CHLAMYDIA SPECIES - LOCATION OF THE EPITOPE ON CHLAMYDIAL LIPOPOLYSACCHARIDE [J].

CALDWELL, HD ;

HITCHCOCK, PJ .

INFECTION AND IMMUNITY, 1984, 44 (02) :306-314

[3] PURIFICATION AND PARTIAL CHARACTERIZATION OF THE MAJOR OUTER-MEMBRANE PROTEIN OF CHLAMYDIA-TRACHOMATIS [J].

CALDWELL, HD ;

KROMHOUT, J ;

SCHACHTER, J .

INFECTION AND IMMUNITY, 1981, 31 (03) :1161-1176

[4] LIPID-METABOLISM IN CHLAMYDIA TRACHOMATIS-INFECTED CELLS - DIRECTED TRAFFICKING OF GOLGI-DERIVED SPHINGOLIPIDS TO THE CHLAMYDIAL INCLUSION [J].

HACKSTADT, T ;

SCIDMORE, MA ;

ROCKEY, DD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4877-4881

[5] Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane [J].

Hackstadt, T ;

Rockey, DD ;

Heinzen, RA ;

Scidmore, MA .

EMBO JOURNAL, 1996, 15 (05) :964-977

[6] The Chlamydia trachomatis parasitophorous vacuolar membrane is not passively permeable to low-molecular-weight compounds [J].

Heinzen, RA ;

Hackstadt, T .

INFECTION AND IMMUNITY, 1997, 65 (03) :1088-1094

[7] Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis [J].

Heinzen, RA ;

Scidmore, MA ;

Rockey, DD ;

Hackstadt, T .

INFECTION AND IMMUNITY, 1996, 64 (03) :796-809

[8] IPAB OF SHIGELLA-FLEXNERI CAUSES ENTRY INTO EPITHELIAL-CELLS AND ESCAPE FROM THE PHAGOCYTIC VACUOLE [J].

HIGH, N ;

MOUNIER, J ;

PREVOST, MC ;

SANSONETTI, PJ .

EMBO JOURNAL, 1992, 11 (05) :1991-1999

[9]

KYTE J, 1982, J MOL BIOL, V157, P1005

[10]

RICHMOND SJ, 1985, FEMS MICROBIOL LETT, V29, P49