Synapse-specific downregulation of NMDA receptors by early experience: A critical period for plasticity of sensory input to olfactory cortex

被引:115
作者
Franks, KM [1 ]
Isaacson, JS [1 ]
机构
[1] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA
关键词
D O I
10.1016/j.neuron.2005.05.024
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Olfaction is required at birth for survival; however, little is known about the maturation of olfactory cortical circuits. Here we show that in vivo sensory experience mediates the development of excitatory transmission in pyramidal neurons of rat olfactory cortex. We find a postnatal critical period during which there is an experience-dependent increase in the contribution of AMPARs versus NMDARs to transmission at primary sensory synapses but not associational inputs. The shift in receptors underlying transmission is mediated by a strong activity-dependent downregulation of NMDARs and modest increase in AMPARs. Sensory activity leads to a loss of "silent" NMDAR-only synapses and an increase in threshold for inducing long-term plasticity. These results indicate the importance of early olfactory experience in the establishment of cortical circuits and could reflect mechanisms governing early olfactory "imprinting."
引用
收藏
页码:101 / 114
页数:14
相关论文
共 63 条
[1]  
[Anonymous], 1998, SYNAPTIC ORG BRAIN
[2]   Cooperation between independent hippocampal synapses is controlled by glutamate uptake [J].
Arnth-Jensen, N ;
Jabaudon, D ;
Scanziani, M .
NATURE NEUROSCIENCE, 2002, 5 (04) :325-331
[3]   NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses [J].
Barth, AL ;
Malenka, RC .
NATURE NEUROSCIENCE, 2001, 4 (03) :235-236
[4]   A postnatal sensitive period for plasticity of cortical afferents but not cortical association fibers in rat piriform cortex [J].
Best, AR ;
Wilson, DA .
BRAIN RESEARCH, 2003, 961 (01) :81-87
[5]   DEVELOPMENT OF BRAIN DEPENDS ON VISUAL ENVIRONMENT [J].
BLAKEMORE, C ;
COOPER, GF .
NATURE, 1970, 228 (5270) :477-+
[6]   General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel [J].
Brunet, LJ ;
Gold, GH ;
Ngai, J .
NEURON, 1996, 17 (04) :681-693
[7]   Cortical plasticity: From synapses to maps [J].
Buonomano, DV ;
Merzenich, MM .
ANNUAL REVIEW OF NEUROSCIENCE, 1998, 21 :149-186
[8]   A CRITICAL PERIOD FOR LONG-TERM POTENTIATION AT THALAMOCORTICAL SYNAPSES [J].
CRAIR, MC ;
MALENKA, RC .
NATURE, 1995, 375 (6529) :325-328
[9]   The effects of variable periods of functional deprivation on olfactory bulb development in rats [J].
Cummings, DM ;
Brunjes, PC .
EXPERIMENTAL NEUROLOGY, 1997, 148 (01) :360-366
[10]   Deriving the glutamate clearance time course from transporter currents in CA1 hippocampal astrocytes: Transmitter uptake gets faster during development [J].
Diamond, JS .
JOURNAL OF NEUROSCIENCE, 2005, 25 (11) :2906-2916