Lack of association between cerebral microbleeds and low serum cholesterol in patients with acute intracerebral hemorrhage

被引:35
作者
Orken, Dilek Necioglu [1 ]
Kenangil, Gulay [1 ]
Uysal, Ender [2 ]
Gundogdu, Lale [1 ]
Erginoz, Ethem [3 ]
Forta, Hulki [1 ]
机构
[1] Sisli Etfal Educ & Res Hosp, Dept Neurol, Istanbul, Turkey
[2] Sisli Etfal Educ & Res Hosp, Dept Radiol, Istanbul, Turkey
[3] Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, Istanbul, Turkey
关键词
Cerebral microbleeds; Intracerebral hemorrhage; Hypocholesterolemia; Leukoaraiosis; Risk factor; T2-ASTERISK-WEIGHTED MR-IMAGES; RISK-FACTORS; ISCHEMIC-STROKE; SIGNAL LOSS; ABNORMALITIES; PREVALENCE; INFARCTION; FREQUENCY; PROGRAM; LESIONS;
D O I
10.1016/j.clineuro.2010.05.004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The association of cerebral microbleeds (CMBs) with intracerebral hemorrhage (ICH) is well known and its relationship with low serum cholesterol in ICH patients might be of interest. Methods: A total of 105 patients with ICH were evaluated. In all subjects cholesterol levels were measured after 12 h of fasting and gradient-echo magnetic resonance imaging (GE-MRI) was performed for detecting CMBs. Results: CMBs were more common among patients with hypertension and leukoaraiosis (p = 0.008 and p = 0.001). Patients with and without CMBs did not differ according to total cholesterol, LDL cholesterol, triglycerides and HDL cholesterol levels. Conclusion: In this study, 61% of Turkish ICH patients had CMBs, which was not associated with lipid profiles. Leukoaraiosis was independently associated with CMBs. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:668 / 671
页数:4
相关论文
共 24 条
[1]  
Chan S, 1996, AM J NEURORADIOL, V17, P1821
[2]  
Fazekas F, 1999, AM J NEURORADIOL, V20, P637
[3]   MR SIGNAL ABNORMALITIES AT 1.5-T IN ALZHEIMER DEMENTIA AND NORMAL AGING [J].
FAZEKAS, F ;
CHAWLUK, JB ;
ALAVI, A ;
HURTIG, HI ;
ZIMMERMAN, RA .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1987, 149 (02) :351-356
[4]  
FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
[5]   VALIDITY OF SERUM TOTAL CHOLESTEROL LEVEL OBTAINED WITHIN 24 HOURS OF ACUTE MYOCARDIAL-INFARCTION [J].
GORE, JM ;
GOLDBERG, RJ ;
MATSUMOTO, AS ;
CASTELLI, WP ;
MCNAMARA, PM ;
DALEN, JE .
AMERICAN JOURNAL OF CARDIOLOGY, 1984, 54 (07) :722-725
[6]   Petechial hemorrhages accompanying lobar hemorrhage: Detection by gradient-echo MRI [J].
Greenberg, SM ;
Finklestein, SP ;
Schaefer, PW .
NEUROLOGY, 1996, 46 (06) :1751-1754
[7]   Low total serum cholesterol and intracerebral hemorrhagic stroke: Is the association confined to elderly men? The Kaiser Permanente Medical Care Program [J].
Iribarren, C ;
Jacobs, DR ;
Sadler, M ;
Claxton, AJ ;
Sidney, S .
STROKE, 1996, 27 (11) :1993-1998
[8]   SERUM-CHOLESTEROL LEVELS AND 6-YEAR MORTALITY FROM STROKE IN 350,977 MEN SCREENED FOR THE MULTIPLE RISK FACTOR INTERVENTION TRIAL [J].
ISO, H ;
JACOBS, DR ;
WENTWORTH, D ;
NEATON, JD ;
COHEN, JD .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (14) :904-910
[9]   Cerebral microbleeds - Prevalence and associations with cardiovascular risk factors in the Framingham Study [J].
Jeerakathil, T ;
Wolf, PA ;
Beiser, A ;
Hald, JK ;
Au, R ;
Kase, CS ;
Massaro, JM ;
DeCarli, C .
STROKE, 2004, 35 (08) :1831-1835
[10]  
Jung KH, 2003, STROKE, V34, P276