Mitotic mechanics: the auroras come into view

被引：251

作者：

Andrews, PD ^{[1
]}

Knatko, E ^{[1
]}

Moore, WJ ^{[1
]}

Swedlow, JR ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr, Div Gene Express & Regulat, Dundee DD1 5EH, Scotland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2003.10.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.

引用

页码：672 / 683

页数：12

共 90 条

[1] INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow [J].

Adams, RR ;

Wheatley, SP ;

Gouldsworthy, AM ;

Kandels-Lewis, SE ;

Carmena, M ;

Smythe, C ;

Gerloff, DL ;

Earnshaw, WD .

CURRENT BIOLOGY, 2000, 10 (17) :1075-1078

[2] Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation [J].

Adams, RR ;

Maiato, H ;

Earnshaw, WC ;

Carmena, M .

JOURNAL OF CELL BIOLOGY, 2001, 153 (04) :865-879

[3] Chromosomal passengers and the (aurora) ABCs of mitosis [J].

Adams, RR ;

Carmena, M ;

Earnshaw, WC .

TRENDS IN CELL BIOLOGY, 2001, 11 (02) :49-54

[4] INCENP centromere and spindle targeting: Identification of essential conserved motifs and involvement of heterochromatin protein HP1 [J].

Ainsztein, AM ;

Kandels-Lewis, SE ;

Mackay, AM ;

Earnshaw, WC .

JOURNAL OF CELL BIOLOGY, 1998, 143 (07) :1763-1774

[5] AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol [J].

Anand, S ;

Penrhyn-Lowe, S ;

Venkitaraman, AR .

CANCER CELL, 2003, 3 (01) :51-62

[6] Drosophila aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis [J].

Berdnik, D ;

Knoblich, JA .

CURRENT BIOLOGY, 2002, 12 (08) :640-647

[7] The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the, spindle checkpoint [J].

Biggins, S ;

Murray, AW .

GENES & DEVELOPMENT, 2001, 15 (23) :3118-3129

[8] The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast [J].

Biggins, S ;

Severin, FF ;

Bhalla, N ;

Sassoon, I ;

Hyman, AA ;

Murray, AW .

GENES & DEVELOPMENT, 1999, 13 (05) :532-544

[9] Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B kinase stimulates Aurora B kinase activity [J].

Bishop, JD ;

Schumacher, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (31) :27577-27580

[10] The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly [J].

Buvelot, S ;

Tatsutani, SY ;

Vermaak, D ;

Biggins, S .

JOURNAL OF CELL BIOLOGY, 2003, 160 (03) :329-339

← 1 2 3 4 5 6 7 8 9 →