Angiogenesis as a therapeutic target

被引：2198

作者：

Ferrara, N

Kerbel, RS

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

[2] Univ Toronto, Toronto, ON M5G 2M9, Canada

[3] Sunnybrook & Womens Coll Hlth Sci Ctr, Toronto, ON M5G 2M9, Canada

来源：

NATURE | 2005年 / 438卷 / 7070期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

D O I：

10.1038/nature04483

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis ( promoting new vessel growth to treat ischaemic disorders) is an exciting frontier of cardiovascular medicine, but further understanding of the mechanisms of vascular morphogenesis is needed first.

引用

收藏

页码：967 / 974

页数：8

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