Are Myocardial Infarction-Associated Single-Nucleotide Polymorphisms Associated With Ischemic Stroke?

被引：26

作者：

Cheng, Yu-Ching

Anderson, Christopher D. ^{[2
,3
,4
]}

Bione, Silvia ^{[5
]}

Keene, Keith ^{[6
,7
]}

Maguire, Jane M. ^{[8
,9
]}

Nalls, Michael ^{[10
]}

Rasheed, Asif ^{[11
]}

Zeginigg, Marion ^{[12
,13
]}

Attia, John ^{[8
]}

Baker, Ross ^{[14
,15
]}

Barlera, Simona ^{[16
]}

Biffi, Alessandro ^{[2
,3
,4
]}

Bookman, Ebony ^{[17
]}

Brott, Thomas G. ^{[18
]}

Brown, Robert D., Jr. ^{[19
]}

Chen, Fang ^{[7
]}

Chen, Wei-Min ^{[7
,20
]}

Ciusani, Emilio ^{[21
]}

Cole, John W. ^{[22
,23
]}

Cortellini, Lynelle ^{[2
,3
,4
]}

Danesh, John ^{[24
]}

Doheny, Kimberly ^{[25
]}

Ferrucci, Luigi ^{[26
]}

Franzosi, Maria Grazia ^{[16
]}

Frossard, Philippe ^{[11
]}

Furie, Karen L. ^{[3
]}

Golledge, Jonathan ^{[27
]}

Hankey, Graeme J. ^{[28
,29
]}

Hernandez, Dena ^{[10
]}

Holliday, Elizabeth G. ^{[8
]}

Hsu, Fang-Chi ^{[30
,31
]}

Jannes, Jim ^{[32
,33
]}

Kamal, Ayeesha ^{[34
]}

Khan, Muhammad Saleem ^{[35
]}

Kittner, Steven J. ^{[22
,23
]}

Koblar, Simon A. ^{[32
,33
]}

Lewis, Martin ^{[32
,33
]}

Lincz, Lisa ^{[8
]}

Lisa, Antonella ^{[5
]}

Matarin, Mar ^{[36
]}

Moscato, Pablo ^{[37
]}

Mychaleckyj, Josyf C. ^{[7
,20
]}

Parati, Eugenio A. ^{[21
]}

Parolo, Silvia ^{[5
]}

Pugh, Elizabeth ^{[25
]}

Rost, Natalia S. ^{[2
,3
,4
]}

Schallert, Michael ^{[6
,7
,12
,13
,39
]}

Schmidt, Helena ^{[12
,13
]}

Scott, Rodney J. ^{[8
]}

Sturm, Jonathan W. ^{[38
]}

机构：

[1] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

[2] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[4] Broad Inst, Program Med & Populat Genet, Cambridge, MA USA

[5] CNR, Inst Mol Genet, Pavia, Italy

[6] Univ Virginia, Dept Med, Charlottesville, VA USA

[7] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA

[8] Univ Newcastle, HMRI, Newcastle, NSW 2300, Australia

[9] Univ Newcastle, Sch Nursing & Midwifery, Newcastle, NSW 2300, Australia

[10] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[11] Ctr Noncommunicable Dis, Karachi, Pakistan

[12] Med Univ Graz, Dept Neurol, Graz, Austria

[13] Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria

[14] Murdoch Univ, Ctr Thrombosis & Haemophilia, Perth, WA, Australia

[15] Royal Perth Hosp, Dept Haematol, Perth, WA, Australia

[16] Ist Ric Farmacol Mario Negri, Milan, Italy

[17] NHGRI, NIH, Rockville, MD USA

[18] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[19] Mayo Clin, Dept Neurol, Rochester, MN USA

[20] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA

[21] Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy

[22] Vet Affairs Med Ctr, Dept Neurol, Baltimore, MD USA

[23] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

[24] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[25] Johns Hopkins Univ, Sch Med, Ctr Inherited Dis Res, Baltimore, MD USA

[26] NIA, Longitudinal Studies Sect, Clin Res Branch, NIH, Bethesda, MD 20892 USA

[27] James Cook Univ, Sch Med, Vasc Biol Unit, Townsville, Qld 4811, Australia

[28] Royal Perth Hosp, Dept Neurol, Perth, WA, Australia

[29] Univ Western Australia, Sch Med & Pharmacol, Crawley, Australia

[30] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA

[31] Wake Forest Sch Med, Ctr Canc Genom, Winston Salem, NC USA

[32] Univ Adelaide, Stroke Res Programme, Sch Med, Adelaide, SA, Australia

[33] Univ Adelaide, Stroke Res Programme, Sch Mol Biomed Sci, Adelaide, SA, Australia

[34] Aga Khan Univ, Neurol Sect, Karachi, Pakistan

[35] Univ London Imperial Coll Sci Technol & Med, ICCRU, London, England

[36] UCL Inst Neurol, Dept Clin & Expt Epilepsy, London, England

[37] Univ Newcastle, Ctr Bioinformat, Newcastle, NSW 2300, Australia

[38] Univ Newcastle, Gosford Hosp, Dept Neurosci, Newcastle, NSW 2300, Australia

[39] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA

[40] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[41] Univ Penn, Philadelphia, PA 19104 USA

来源：

STROKE | 2012年 / 43卷 / 04期

基金：

奥地利科学基金会; 美国国家卫生研究院; 澳大利亚国家健康与医学研究理事会;

关键词：

cerebral infarct; genetics; ischemia; GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; VITAMIN INTERVENTION; SEQUENCE VARIANTS; HEART-DISEASE; CLASSIFICATION; PREVENTION; SUBTYPES; HISTORY; UPDATE;

D O I：

10.1161/STROKEAHA.111.632075

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Methods-Meta-analyses of the associations between the 11 MI-associated SNPs and IS were performed using 6865 cases and 11 395 control subjects recruited from 9 studies. SNPs were either genotyped directly or imputed; in a few cases a surrogate SNP in high linkage disequilibrium was chosen. Logistic regression was performed within each study to obtain study-specific beta s and standard errors. Meta-analysis was conducted using an inverse variance weighted approach assuming a random effect model. Results-Despite having power to detect odds ratio of 1.09-1.14 for overall IS and 1.20-1.32 for major stroke subtypes, none of the SNPs were significantly associated with overall IS and/or stroke subtypes after adjusting for multiple comparisons. Conclusions-Our results suggest that the major common loci associated with MI risk do not have effects of similar magnitude on overall IS but do not preclude moderate associations restricted to specific IS subtypes. Disparate mechanisms may be critical in the development of acute ischemic coronary and cerebrovascular events. (Stroke. 2012; 43:980-986.)

引用

页码：980 / U143

页数：26

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