β-peptides:: From structure to function

被引：1768

作者：

Cheng, RP

Gellman, SH ^{[1
]}

DeGrado, WF

机构：

[1] Univ Penn, Sch Med, Dept Biochem & Biophys, Johnson Res Fdn, Philadelphia, PA 19104 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 10期

关键词：

D O I：

10.1021/cr000045i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The techniques used for designing biomimetic polymers which showed both secondary and tertiary structures analogous to natural proteins were discussed. A series of cyclic β-peptides and mixed α- and β-peptides that self-assemble to form tubular architectures were also studied. The results revealed that the polymeric β-peptides were capable of adopting stable helical structures.

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页码：3219 / 3232

页数：14

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