Antrum- and corpus mucosa-infiltrating CD4+ lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype

被引：132

作者：

Sommer, F

Faller, G

Konturek, P

Kirchner, T

Hahn, EG

Zeus, J

Röllinghoff, M

Lohoff, M

机构：

[1] Univ Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Inst Pathol, D-91054 Erlangen, Germany

[3] Univ Erlangen Nurnberg, Med Klin 1, D-91054 Erlangen, Germany

[4] Praxis Innere Med, Erlangen, Germany

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 11期

关键词：

D O I：

10.1128/IAI.66.11.5543-5546.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, cytokine patterns produced by CD4(+) T cells isolated from antrum or corpus gastral biopsy specimens of 10 patients with Helicobacter pylori-positive gastritis were compared. To this end, expression of intracellular cytokines (interleukin-4 [IL-4] and gamma interferon) and of CD4 was assessed by flow cytometry. Ten to 60% of the isolated CD4(+) T cells produced gamma interferon upon stimulation. With the exception of one patient, IL-4-positive CD4(+) cells were not detected. Therefore, CD4(+) cells infiltrating antrum and corpus stomach mucosa during H. pylori infection show a Th1 phenotype. This polarized Th1-type response may contribute to the inability of the immune system to eradicate H. pylori infection.

引用

收藏

页码：5543 / 5546

页数：4

相关论文

共 27 条

[1] Molecular mimicry between Helicobacter pylori and the host [J].

Appelmelk, BJ ;

Negrini, R ;

Moran, AP ;

Kuipers, EJ .

TRENDS IN MICROBIOLOGY, 1997, 5 (02) :70-73

[2] Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype [J].

Bamford, KB ;

Fan, XJ ;

Crowe, SE ;

Leary, JF ;

Gourley, WK ;

Luthra, GK ;

Brooks, EG ;

Graham, DY ;

Reyes, VE ;

Ernst, PB .

GASTROENTEROLOGY, 1998, 114 (03) :482-492

[3] MOLECULAR CHARACTERIZATION OF THE 128-KDA IMMUNODOMINANT ANTIGEN OF HELICOBACTER-PYLORI-ASSOCIATED WITH CYTOTOXICITY AND DUODENAL-ULCER [J].

COVACCI, A ;

CENSINI, S ;

BUGNOLI, M ;

PETRACCA, R ;

BURRONI, D ;

MACCHIA, G ;

MASSONE, A ;

PAPINI, E ;

XIANG, ZY ;

FIGURA, N ;

RAPPUOLI, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (12) :5791-5795

[4]

COVER TL, 1992, J BIOL CHEM, V267, P10570

[5] Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer [J].

DElios, MM ;

Manghetti, M ;

Almerigogna, F ;

Amedei, A ;

Costa, F ;

Burroni, D ;

Baldari, CT ;

Romagnani, S ;

Telford, JL ;

DelPrete, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (07) :1751-1755

[6]

DElios MM, 1997, J IMMUNOL, V158, P962

[7] HELICOBACTER PYLORI-SPECIFIC CD4(+) T-CELL CLONES FROM PERIPHERAL-BLOOD AND GASTRIC BIOPSIES [J].

DITOMMASO, A ;

XIANG, ZY ;

BUGNOLI, M ;

PILERI, P ;

FIGURA, N ;

BAYELI, PF ;

RAPPUOLI, R ;

ABRIGNANI, S ;

DEMAGISTRIS, MT .

INFECTION AND IMMUNITY, 1995, 63 (03) :1102-1106

[8] Antigastric autoantibodies in Helicobacter pylori infection: implications of histological and clinical parameters of gastritis [J].

Faller, G ;

Steininger, H ;

Kranzlein, J ;

Maul, H ;

Kerkau, T ;

Hensen, J ;

Hahn, EG ;

Kirchner, T .

GUT, 1997, 41 (05) :619-623

[9] The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells:: A mechanism for T helper cell type 1-mediated damage [J].

Fan, XJ ;

Crowe, SE ;

Behar, S ;

Gunasena, H ;

Ye, G ;

Haeberle, H ;

Van Houten, N ;

Gourley, WK ;

Ernst, PB ;

Reyes, VE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (10) :1659-1669

[10] GASTRIC T-LYMPHOCYTE RESPONSES TO HELICOBACTER-PYLORI IN PATIENTS WITH HELICOBACTER-PYLORI COLONIZATION [J].

FAN, XJ ;

CHUA, A ;

SHAHI, CN ;

MCDEVITT, J ;

KEELING, PWN ;

KELLEHER, D .

GUT, 1994, 35 (10) :1379-1384