The angiotensin I converting enzyme gene as a susceptibility factor for dementia

被引：36

作者：

Richard, F

Fromentin-David, I

Ricolfi, F

Ducimetière, P

Di Menza, C

Amouyel, P

Helbecque, N

机构：

[1] Inst Pasteur, INSERM U508, F-59019 Lille, France

[2] Assistance Publ Hop Paris, Ctr Hosp Emile Roux, Serv Gerontol Clin, Limeil Brevannes, France

[3] Assistance Publ Hop Paris, Creteil, France

[4] Ctr Hosp Henri Mondor, Serv Neuroradiol, Creteil, France

[5] Hop Paul Brousse, INSERM U258, Villejuif, France

来源：

NEUROLOGY | 2001年 / 56卷 / 11期

关键词：

D O I：

10.1212/WNL.56.11.1593

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The frequency of a genetic susceptibility vascular factor, the deletion (D) allele of the angiotensin I converting enzyme gene (ACE), coding for a key enzyme of the renin angiotensin system, was characterized in two independent case-control studies. The results of the current study suggest that bearing at least one ACE D allele is a risk factor to develop dementia for subjects older than 74 years. This observation reinforces the hypothesis of a major implication of vascular risk factors in the occurrence of all types of dementia.

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页码：1593 / 1595

页数：3

相关论文

共 10 条

[1] The deletion allele of the angiotensin I converting enzyme gene as a genetic susceptibility factor for cognitive impairment [J].

Amouyel, P ;

Richard, F ;

Cottel, D ;

Amant, C ;

Codron, V ;

Helbecque, N .

NEUROSCIENCE LETTERS, 1996, 217 (2-3) :203-205

[2] ANGIOTENSIN CONVERTING ENZYME DENSITY IS INCREASED IN TEMPORAL CORTEX FROM PATIENTS WITH ALZHEIMERS-DISEASE [J].

BARNES, NM ;

CHENG, CHK ;

COSTALL, B ;

NAYLOR, RJ ;

WILLIAMS, TJ ;

WISCHIK, CM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 200 (2-3) :289-292

[3] Vascular risk factors for Alzheimer's disease: An epidemiologic perspective [J].

Breteler, MMB .

NEUROBIOLOGY OF AGING, 2000, 21 (02) :153-160

[4] ANGIOTENSIN-I-CONVERTING ENZYME IN HUMAN CIRCULATING MONONUCLEAR-CELLS - GENETIC-POLYMORPHISM OF EXPRESSION IN LYMPHOCYTES-T [J].

COSTEROUSSE, O ;

ALLEGRINI, J ;

LOPEZ, M ;

ALHENCGELAS, F .

BIOCHEMICAL JOURNAL, 1993, 290 :33-40

[5] Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease [J].

Crawford, F ;

Abdullah, L ;

Schinka, J ;

Suo, ZM ;

Gold, M ;

Duara, R ;

Mullan, M .

NEUROSCIENCE LETTERS, 2000, 280 (03) :215-219

[6] The ACE gene and Alzheimer's disease susceptibility [J].

Narain, Y ;

Yip, A ;

Murphy, T ;

Brayne, C ;

Easton, D ;

Evans, JG ;

Xuereb, J ;

Cairns, N ;

Esiri, MM ;

Furlong, RA ;

Rubinsztein, DC .

JOURNAL OF MEDICAL GENETICS, 2000, 37 (09) :695-697

[7] Angiotensin-converting enzyme and cardiovascular disease risk [J].

O'Malley, JP ;

Maslen, CL ;

Illingworth, DR .

CURRENT OPINION IN LIPIDOLOGY, 1999, 10 (05) :407-415

[8] Angiotensin converting enzyme deletion allele in different kinds of dementia disorders [J].

Palumbo, B ;

Cadini, D ;

Nocentini, G ;

Filipponi, E ;

Fravolini, ML ;

Senin, U .

NEUROSCIENCE LETTERS, 1999, 267 (02) :97-100

[9] Effect of the angiotensin I-converting enzyme I/D polymorphism on cognitive decline [J].

Richard, F ;

Berr, C ;

Amant, C ;

Helbecque, N ;

Amouyel, P ;

Alpérovitch, A .

NEUROBIOLOGY OF AGING, 2000, 21 (01) :75-80

[10]

TIRET L, 1992, AM J HUM GENET, V51, P197