Specialization and evolution of endogenous small RNA pathways

被引:482
作者
Chapman, Elisabeth J.
Carrington, James C.
机构
[1] Oregon State Univ, Ctr Genome Res & Biocomp, Corvallis, OR 97331 USA
[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
基金
美国国家科学基金会; 美国国家卫生研究院; 欧盟地平线“2020”;
关键词
D O I
10.1038/nrg2179
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The specificity of RNA silencing is conferred by small RNA guides that are processed from structured RNA or dsRNA. The core components for small RNA biogenesis and effector functions have proliferated and specialized in eukaryotic lineages, resulting in diversified pathways that control expression of endogenous and exogenous genes, invasive elements and viruses, and repeated sequences. Deployment of small RNA pathways for spatiotemporal regulation of the transcriptome has shaped the evolution of eukaryotic genomes and contributed to the complexity of multicellular organisms.
引用
收藏
页码:884 / 896
页数:13
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