Transcription-associated protein families are primarily taxon-specific

被引：23

作者：

Coulson, RMR ^{[1
]}

Enright, AJ ^{[1
]}

Ouzounis, CA ^{[1
]}

机构：

[1] European Bioinformat Inst, EMBL Cambridge Outstn, Res Programme, Computat Genom Grp, Cambridge CB10 1SD, England

来源：

BIOINFORMATICS | 2001年 / 17卷 / 01期

关键词：

D O I：

10.1093/bioinformatics/17.1.95

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms controlling gene regulation appear to be fundamentally different in eukaryotes and prokaryotes (Struhl (1999) Cell, 98, 1-4). To investigate this diversity further, we have analysed the distribution of all known transcription-associated proteins (TAPs), as reflected by sequence database annotations. Our results for the primary phylogenetic domains (Archaea, Bacteria and Eukaryota) show that TAP families are mostly taxon-specific and very few transcriptional regulators are common across these domains.

引用

收藏

页码：95 / 97

页数：3

相关论文

共 10 条

[1] Transcriptional regulation of an archaeal operon in vivo and in vitro [J].

Bell, SD ;

Cairns, SS ;

Robson, RL ;

Jackson, SP .

MOLECULAR CELL, 1999, 4 (06) :971-982

[2] GeneRAGE: a robust algorithm for sequence clustering and domain detection [J].

Enright, AJ ;

Ouzounis, CA .

BIOINFORMATICS, 2000, 16 (05) :451-457

[3] Protein interaction maps for complete genomes based on gene fusion events [J].

Enright, AJ ;

Iliopoulos, I ;

Kyrpides, NC ;

Ouzounis, CA .

NATURE, 1999, 402 (6757) :86-90

[4] ORIGIN AND EVOLUTION OF ORGANELLE GENOMES [J].

GRAY, MW .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1993, 3 (06) :884-890

[5] Transcription in Archaea [J].

Kyrpides, NC ;

Ouzounis, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8545-8550

[6] How can we use our growing understanding of gene transcription to discover effective new medicines? [J].

Latchman, DS .

CURRENT OPINION IN BIOTECHNOLOGY, 1997, 8 (06) :713-717

[7] ISOLATION OF CDNA-ENCODING A BINDING-PROTEIN SPECIFIC TO 5'-PHOSPHORYLATED SINGLE-STRANDED-DNA WITH G-RICH SEQUENCES [J].

MIZUTA, TR ;

FUKITA, Y ;

MIYOSHI, T ;

SHIMIZU, A ;

HONJO, T .

NUCLEIC ACIDS RESEARCH, 1993, 21 (08) :1761-1766

[8] Arabidopsis transcription factors:: Genome-wide comparative analysis among eukaryotes [J].

Riechmann, JL ;

Heard, J ;

Martin, G ;

Reuber, L ;

Jiang, CZ ;

Keddie, J ;

Adam, L ;

Pineda, O ;

Ratcliffe, OJ ;

Samaha, RR ;

Creelman, R ;

Pilgrim, M ;

Broun, P ;

Zhang, JZ ;

Ghandehari, D ;

Sherman, BK ;

Yu, CL .

SCIENCE, 2000, 290 (5499) :2105-2110

[9] Fundamentally different logic of gene regulation in eukaryotes and prokaryotes [J].

Struhl, K .

CELL, 1999, 98 (01) :1-4

[10] Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation [J].

Zhang, JJ ;

Zhao, YM ;

Chait, BT ;

Lathem, WW ;

Ritzi, M ;

Knippers, R ;

Darnell, JE .

EMBO JOURNAL, 1998, 17 (23) :6963-6971