Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice

被引:119
作者
Gunshin, H
Starr, CN
DiRenzo, C
Fleming, MD
Jin, J
Greer, EL
Sellers, VM
Galica, SM
Andrews, NC [1 ]
机构
[1] Harvard Univ, Sch Med, Childrens Hosp,Dana Farber Canc Inst, Karp Family Res Labs RM 8 125, Boston, MA 02115 USA
[2] Howard Hughes Med Inst, Boston, MA 02115 USA
关键词
D O I
10.1182/blood-2005-02-0716
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mammalian northeme iron absorption requires reduction of dietary iron for uptake by the divalent metal ion transport system in the intestine. This was thought to be mediated by duodenal cytochrome b (Cybrd1), a ferric reductase enzyme resident on the luminal surface of intestinal absorptive cells. To test its importance in vivo, we inactivated the murine Cybrd1 gene and assessed tissue iron stores in Cybrd1-null mice. We found that loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency. We conclude that other mechanisms must be available for the reduction of dietary iron.
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页码:2879 / 2883
页数:5
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