Targeting EGFR in non-small-cell lung cancer

被引:23
作者
Doroshow, JH [1 ]
机构
[1] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA
关键词
D O I
10.1056/NEJMe058113
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:200 / 202
页数:3
相关论文
共 12 条
[1]   Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer [J].
Cappuzzo, F ;
Hirsch, FR ;
Rossi, E ;
Bartolini, S ;
Ceresoli, GL ;
Bemis, L ;
Haney, J ;
Witta, S ;
Danenberg, K ;
Domenichini, I ;
Ludovini, V ;
Magrini, E ;
Gregorc, V ;
Doglioni, C ;
Sidoni, A ;
Tonato, M ;
Franklin, WA ;
Crino, L ;
Bunn, PA ;
Varella-Garcia, M .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (09) :643-655
[2]   ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines [J].
Engelman, JA ;
Jänne, PA ;
Mermel, C ;
Pearlberg, J ;
Mukohara, T ;
Fleet, C ;
Cichowski, K ;
Johnson, BE ;
Cantley, LC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (10) :3788-3793
[3]   Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2 [J].
Herbst, RS ;
Giaccone, G ;
Schiller, JH ;
Natale, RB ;
Miller, V .
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (05) :785-794
[4]  
HERBST RS, 2004, P AN M AM SOC CLIN, V23, P617
[5]   Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer - A randomized trial [J].
Kris, MG ;
Natale, RB ;
Herbst, RS ;
Lynch, TJ ;
Prager, D ;
Belani, CP ;
Schiller, JH ;
Kelly, K ;
Spiridonidis, H ;
Sandler, A ;
Albain, KS ;
Cella, D ;
Wolf, MK ;
Averbuch, SD ;
Ochs, JJ ;
Kay, AC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (16) :2149-2158
[6]   Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].
Lynch, TJ ;
Bell, DW ;
Sordella, R ;
Gurubhagavatula, S ;
Okimoto, RA ;
Brannigan, BW ;
Harris, PL ;
Haserlat, SM ;
Supko, JG ;
Haluska, FG ;
Louis, DN ;
Christiani, DC ;
Settleman, J ;
Haber, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139
[7]   EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].
Paez, JG ;
Jänne, PA ;
Lee, JC ;
Tracy, S ;
Greulich, H ;
Gabriel, S ;
Herman, P ;
Kaye, FJ ;
Lindeman, N ;
Boggon, TJ ;
Naoki, K ;
Sasaki, H ;
Fujii, Y ;
Eck, MJ ;
Sellers, WR ;
Johnson, BE ;
Meyerson, M .
SCIENCE, 2004, 304 (5676) :1497-1500
[8]   Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions [J].
Pao, W ;
Miller, VA .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (11) :2556-2568
[9]   Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer [J].
Pérez-Soler, R ;
Chachoua, A ;
Hammond, LA ;
Rowinsky, EK ;
Huberman, M ;
Karp, D ;
Rigas, J ;
Clark, GM ;
Santabàrbara, P ;
Bonomi, P .
JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (16) :3238-3247
[10]   Erlotinib in previously treated non-small-cell lung cancer [J].
Shepherd, FA ;
Pereira, JR ;
Ciuleanu, T ;
Tan, EH ;
Hirsh, V ;
Thongprasert, S ;
Campos, D ;
Maoleekoonpiroj, S ;
Smylie, M ;
Martins, R ;
van Kooten, M ;
Dediu, M ;
Findlay, B ;
Tu, DS ;
Johnston, D ;
Bezjak, A ;
Clark, G ;
Santabárbara, P ;
Seymour, L .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (02) :123-132