Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23

被引：200

作者：

Meder, W

Wendland, M

Busmann, A

Kutzleb, C

Spodsberg, N

John, H

Richter, R

Schleuder, D

Meyer, M

Forssmann, WG

机构：

[1] IPF PharmacCeut GmbH, D-30625 Hannover, Germany

[2] Pharis Biotec GmbH, D-30625 Hannover, Germany

[3] Appl Biosyst Inc, D-64293 Hannover, Germany

来源：

FEBS LETTERS | 2003年 / 555卷 / 03期

关键词：

ligand; orphan receptor; ChemR23; TIG2; GPCR;

D O I：

10.1016/S0014-5793(03)01312-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The orphan receptor ChemR23 is a G-protein coupled receptor (GPCR) with homology to neuropeptide and chemoattractant receptors. Tazarotene, a synthetic retinoid activating retinoic acid receptor (RAR), up-regulates tazarotene-induced gene-2 (TIG2). The function and molecular target of this protein are now described. By means of reverse pharmacology screening using a peptide library generated from human hemofiltrate, we have isolated and identified TIG2 as the natural ligand of ChemR23 and report the specific molecular form of the bioactive, circulating TIG2, representing the amino-acid residues 21 to 154 of the 163 amino acid-containing prepropeptide. Based on the expression pattern of ChemR23 and TIG2, the physiological role in bone development, immune and inflammatory responses and the maintenance of skin is now being investigated. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：495 / 499

页数：5

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