Islands of linkage disequilibrium

被引:215
作者
Goldstein, DB [1 ]
机构
[1] UCL, Dept Biol, London NW1 2HE, England
关键词
D O I
10.1038/ng1001-109
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A detailed knowledge of patterns of linkage disequilibrium in human populations is widely seen as a prerequisite for effective population-based disease gene mapping. New data suggest that linkage disequilibrium is highly structured into discrete blocks of sequence separated by hot spots of recombination.
引用
收藏
页码:109 / 111
页数:3
相关论文
共 11 条
[1]   Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase [J].
Clark, AG ;
Weiss, KM ;
Nickerson, DA ;
Taylor, SL ;
Buchanan, A ;
Stengård, J ;
Salomaa, V ;
Vartiainen, E ;
Perola, M ;
Boerwinkle, E ;
Sing, CF .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (02) :595-612
[2]   High-resolution haplotype structure in the human genome [J].
Daly, MJ ;
Rioux, JD ;
Schaffner, SE ;
Hudson, TJ ;
Lander, ES .
NATURE GENETICS, 2001, 29 (02) :229-232
[3]   The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons [J].
Finta, C ;
Zaphiropoulos, PG .
GENE, 2000, 260 (1-2) :13-23
[4]   Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex [J].
Jeffreys, AJ ;
Kauppi, L ;
Neumann, R .
NATURE GENETICS, 2001, 29 (02) :217-222
[5]   Haplotype tagging for the identification of common disease genes [J].
Johnson, GCL ;
Esposito, L ;
Barratt, BJ ;
Smith, AN ;
Heward, J ;
Di Genova, G ;
Ueda, H ;
Cordell, HJ ;
Eaves, IA ;
Dudbridge, F ;
Twells, RCJ ;
Payne, F ;
Hughes, W ;
Nutland, S ;
Stevens, H ;
Carr, P ;
Tuomilehto-Wolf, E ;
Tuomilehto, J ;
Gough, SCL ;
Clayton, DG ;
Todd, JA .
NATURE GENETICS, 2001, 29 (02) :233-237
[6]   Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression [J].
Kuehl, P ;
Zhang, J ;
Lin, Y ;
Lamba, J ;
Assem, M ;
Schuetz, J ;
Watkins, PB ;
Daly, A ;
Wrighton, SA ;
Hall, SD ;
Maurel, P ;
Relling, M ;
Brimer, C ;
Yasuda, K ;
Venkataramanan, R ;
Strom, S ;
Thummel, K ;
Boguski, MS ;
Schuetz, E .
NATURE GENETICS, 2001, 27 (04) :383-391
[7]   Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans [J].
Paulussen, A ;
Lavrijsen, K ;
Bohets, H ;
Hendrickx, J ;
Verhasselt, P ;
Luyten, W ;
Konings, F ;
Armstrong, M .
PHARMACOGENETICS, 2000, 10 (05) :415-424
[8]   Linkage disequilibrium in the human genome [J].
Reich, DE ;
Cargill, M ;
Bolk, S ;
Ireland, J ;
Sabeti, PC ;
Richter, DJ ;
Lavery, T ;
Kouyoumjian, R ;
Farhadian, SF ;
Ward, R ;
Lander, ES .
NATURE, 2001, 411 (6834) :199-204
[9]   Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease [J].
Rioux, JD ;
Daly, MJ ;
Silverberg, MS ;
Lindblad, K ;
Steinhart, H ;
Cohen, Z ;
Delmonte, T ;
Kocher, K ;
Miller, K ;
Guschwan, S ;
Kulbokas, EJ ;
O'Leary, S ;
Winchester, E ;
Dewar, K ;
Green, T ;
Stone, V ;
Chow, C ;
Cohen, A ;
Langelier, D ;
Lapointe, G ;
Gaudet, D ;
Faith, J ;
Branco, N ;
Bull, SB ;
McLeod, RS ;
Griffiths, AM ;
Bitton, A ;
Greenberg, GR ;
Lander, ES ;
Siminovitch, KA ;
Hudson, TJ .
NATURE GENETICS, 2001, 29 (02) :223-228
[10]   Haplotype variation and linkage disequilibrium in 313 human genes [J].
Stephens, JC ;
Schneider, JA ;
Tanguay, DA ;
Choi, J ;
Acharya, T ;
Stanley, SE ;
Jiang, RH ;
Messer, CJ ;
Chew, A ;
Han, JH ;
Duan, JC ;
Carr, JL ;
Lee, MS ;
Koshy, B ;
Kumar, AM ;
Zhang, G ;
Newell, WR ;
Windemuth, A ;
Xu, CB ;
Kalbfleisch, TS ;
Shaner, SL ;
Arnold, K ;
Schulz, V ;
Drysdale, CM ;
Nandabalan, K ;
Judson, RS ;
Ruaño, G ;
Vovis, GF .
SCIENCE, 2001, 293 (5529) :489-493