Breast cancer risk polymorphisms and interaction with ionizing radiation among US Radiologic Technologists

被引：27

作者：

Bhatti, Parveen ^{[1
]}

Doody, Michele M. ^{[1
]}

Alexander, Bruce H. ^{[2
]}

Yuenger, Jeff ^{[3
]}

Simon, Steven L. ^{[1
]}

Weinstock, Robert M. ^{[4
]}

Rosenstein, Marvin ^{[4
]}

Stovall, Marilyn ^{[5
]}

Abendfl, Michael ^{[1
,6
]}

Preston, Dale L. ^{[7
]}

Pharoah, Paul ^{[8
]}

Struewing, Jeffery P. ^{[9
]}

Sigurdson, Alice J. ^{[1
]}

机构：

[1] NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[2] Univ Minnesota, Sch Publ Hlth, Div Environm Hlth Sci, Minneapolis, MN USA

[3] Lab Translat Genom, Core Genotyping Facil, Gaithersburg, MD USA

[4] Univ Texas MD Anderson Canc Ctr, Res Triangle Inst, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA

[6] Bundeswehr Inst Radiobiol, Munich, Germany

[7] HiroSoft Int Corp, Seattle, WA USA

[8] Strangeways Res Lab, Canc Res UK, Cambridge CB1 4RN, England

[9] NCI, Lab Populat Genet, Canc Res Ctr, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2008年 / 17卷 / 08期

关键词：

D O I：

10.1158/1055-9965.EPI-08-0300

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway.

引用

页码：2007 / 2011

页数：5

共 19 条

[1] Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in US radiologic technologists [J].

Bhatti, Parveen ;

Struewing, Jeffery P. ;

Alexander, Bruce H. ;

Hauptmann, Michael ;

Bowen, Laura ;

Mateus-Pereira, Lutecia H. ;

Pineda, Marbin A. ;

Simon, Steven L. ;

Weinstock, Robert M. ;

Rosenstein, Marvin ;

Stovall, Marilyn ;

Preston, Dale L. ;

Linet, Martha S. ;

Doody, Michele M. ;

Sigurdson, Alice J. .

INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (01) :177-182

[2] Retrospective biodosimetry among United States radiologic technologists [J].

Bhatti, Parveen ;

Preston, Dale L. ;

Doody, Michele Morin ;

Hauptmann, Michael ;

Kampa, Diane ;

Alexander, Bruce H. ;

Petibone, Dayton ;

Simon, Steven L. ;

Weinstock, Robert M. ;

Bouville, Andre ;

Yong, Lee C. ;

Freedman, D. Michal ;

Mabuchi, Kiyohiko ;

Linet, Martha S. ;

Edwards, Alan A. ;

Tucker, James D. ;

Sigurdson, Alice J. .

RADIATION RESEARCH, 2007, 167 (06) :727-734

[3] DIAGNOSTIC-X-RAY PROCEDURES AND RISK OF LEUKEMIA, LYMPHOMA, AND MULTIPLE-MYELOMA [J].

BOICE, JD ;

MORIN, MM ;

GLASS, AG ;

FRIEDMAN, GD ;

STOVALL, M ;

HOOVER, RN ;

FRAUMENI, JF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 265 (10) :1290-1294

[4] Breast cancer incidence in US radiologic technologists [J].

Doody, Michele Morin ;

Freedman, D. Michal ;

Alexander, Bruce H. ;

Hauptmann, Michael ;

Miller, Jeremy S. ;

Rao, R. Sowmya ;

Mabuchi, Kiyohiko ;

Ron, Elaine ;

Sigurdson, Alice J. ;

Linet, Martha S. .

CANCER, 2006, 106 (12) :2707-2715

[5] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[6] The H19 gene:: regulation and function of a non-coding RNA [J].

Gabory, A. ;

Ripoche, M. -A. ;

Yoshimizu, T. ;

Dandolo, L. .

CYTOGENETIC AND GENOME RESEARCH, 2006, 113 (1-4) :188-193

[7] A common genetic risk factor for colorectal and prostate cancer [J].

Haiman, Christopher A. ;

Le Marchand, Loic ;

Yamamato, Jennifer ;

Stram, Daniel O. ;

Sheng, Xin ;

Kolonel, Laurence N. ;

Wu, Anna H. ;

Reich, David ;

Henderson, Brian E. .

NATURE GENETICS, 2007, 39 (08) :954-956

[8] Radiation-induced genomic instability and its implications for radiation carcinogenesis [J].

Huang, L ;

Snyder, AR ;

Morgan, WF .

ONCOGENE, 2003, 22 (37) :5848-5854

[9]

LAND CE, 1987, J CHRON DIS S2, V40, P45

[10] Changes in the DNA methylation profile of the rat H19 gene upstream region during development and transgenic hepatocarcinogenesis and its role in the imprinted transcriptional regulation of the H19 gene [J].

Manoharan, H ;

Babcock, K ;

Pitot, HC .

MOLECULAR CARCINOGENESIS, 2004, 41 (01) :1-16

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