The expanding RNA polymerase III transcriptome

被引：401

作者：

Dieci, Giorgio ^{[1
]}

Fiorino, Gloria ^{[1
]}

Castelnuovo, Manuele ^{[2
]}

Teichmann, Martin ^{[3
]}

Pagano, Aldo ^{[2
,4
]}

机构：

[1] Univ Parma, Dipartmento Biochim & Biol Mol, I-43100 Parma, Italy

[2] Univ Genoa, Dipartimento Oncol Biol & Genet, I-16132 Genoa, Italy

[3] Univ Bordeaux 2, IECB, F-33607 Pessac, France

[4] Ist Nazl Ric Canc, I-16132 Genoa, Italy

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 12期

关键词：

D O I：

10.1016/j.tig.2007.09.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The role of RNA polymerase (Pol) III in eukaryotic transcription is commonly thought of as being restricted to a small set of highly expressed, housekeeping nonprotein-coding (nc)RNA genes. Recent studies, however, have remarkably expanded the set of known Pol III-synthesized ncRNAs, suggesting that gene-specific Pol III regulation is more common than previously appreciated. Newly identified Pol III transcripts include small nucleolar RNAs, microRNAs, short interspersed nuclear element-encoded or tRNA-derived RNAs and novel classes of ncRNA that can display significant sequence complementarity to protein-coding genes and might thus regulate their expression. The extent of the Pol III transcriptome, the complexity of its regulation and its influence on cell physiology, development and disease are emerging as new areas for future research.

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收藏

页码：614 / 622

页数：9

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