Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy

被引：308

作者：

Ogg, GS

Jin, X

Bonhoeffer, S

Moss, P

Nowak, MA

Monard, S

Segal, JP

Cao, Y

Rowland-Jones, SL

Hurley, A

Markowitz, M

Ho, DD

McMichael, AJ ^{[1
]}

Nixon, DF

机构：

[1] Nuffield Dept Med, Inst Mol Med, Oxford OX3 9DS, England

[2] Inst Adv Study, Princeton, NJ 08540 USA

[3] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.73.1.797-800.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Little is known of the changes in human immunodeficiency virus type 1 (HIV-1)-specific effector cytotoxic T lymphocytes (CTL) after potent antiretroviral therapy. Using HLA/peptide tetrameric complexes, we show that after starting treatment, there are early rapid fluctuations in the HIV-l-specific CTL response which last I to 2 weeks. These fluctuations are followed by an exponential decay (median half-life, 45 days) of HIV-1-specific CTL which continues while viremia remains undetectable. These data have implications for the immunological control of drug-resistant virus.

引用

收藏

页码：797 / 800

页数：4

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