An ecological and evolutionary perspective on human-microbe mutualism and disease

被引：1121

作者：

Dethlefsen, Les

McFall-Ngai, Margaret

Relman, David A. ^{[1
]}

机构：

[1] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[2] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA

[3] Stanford Univ, Dept Med, Stanford, CA 94305 USA

[4] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

来源：

NATURE | 2007年 / 449卷 / 7164期

关键词：

D O I：

10.1038/nature06245

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The microbial communities of humans are characteristic and complex mixtures of microorganisms that have co-evolved with their human hosts. The species that make up these communities vary between hosts as a result of restricted migration of microorganisms between hosts and strong ecological interactions within hosts, as well as host variability in terms of diet, genotype and colonization history. The shared evolutionary fate of humans and their symbiotic bacteria has selected for mutualistic interactions that are essential for human health, and ecological or genetic changes that uncouple this shared fate can result in disease. In this way, looking to ecological and evolutionary principles might provide new strategies for restoring and maintaining human health.

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页码：811 / 818

页数：8

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